Erwin F. Wagner
PhD, Dipl Ing, Medical University of Vienna
Erwin Wagner, PhD, Dipl Ing is an internationally recognized scientist, who pioneered technologies for modifying the information encoded in mouse DNA to study human disease.
His research provided the scientific community with highly instructive mouse models for complex diseases such as psoriasis or cancer. This understanding at the molecular and whole body level is essential to define which gene and processes cause the disease and how they can be targeted for preventive, diagnostic and therapeutic approaches.
Erwin Wagner established powerful mouse models for psoriasis/psoriatic arthritis, bone cancer and fibrosis. He made ground-breaking discoveries on the roles of AP-1 (Fos/Jun) transcription factors, which determine how cells and tissues divide, specialize and die. His research also provided key insights to the pathogenesis of cachexia, lung fibrosis and liver cancer, offering new therapeutic interventions. His studies expanded to signalling molecules that transmit information in the body, such as the EGF-receptor, and discovered novel functions in skin development and cancer. Collectively, the mouse models of disease developed by Erwin Wagner led to important discoveries in embryonic development, hyper-proliferative diseases, and the interplay between inflammation, metabolism and cancer.
Erwin Wagner received his PhD degree in Biochemistry and Molecular Biology from the University of Graz, Austria. He did his postdoctoral work in developmental biology with Dr. Mintz at the Fox Chase Cancer Centre in Philadelphia, USA. He held leadership positions at the EMBL, Heidelberg, Germany, was a founding member of the IMP in Vienna, Austria and Vice Director at the CNIO in Madrid, Spain. He is currently Professor at the Medical University of Vienna, Department of Dermatology and Department of Laboratory Medicine.
Find out more about Dr Wagner’s team and research focus here.