Publications

CANCERPREV-related publications and highlights by participating laboratories

Altun Mikael

• Giovannucci TA, Salomons FA, Haraldsson M, Elfman LHM, Wickström M, Young P, Lundbäck T, Eirich J, Altun M, Jafari R, Gustavsson AL, Johnsen JI, Dantuma NP. Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound. Cell Death Dis. 2021 Oct 6;12(10):914. doi: 10.1038/s41419-021-04191-9. PMID: 34615851; PMCID: PMC8494907.
• Kanellis DC, Espinoza JA, Zisi A, Sakkas E, Bartkova J, Katsori AM, Boström J, Dyrskjøt L, Broholm H, Altun M, Elsässer SJ, Lindström MS, Bartek J. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output. Sci Adv. 2021 Aug 4;7(32):eabf7561. doi: 10.1126/sciadv.abf7561. PMID: 34348895; PMCID: PMC8336962.
• Visnes T, Benítez-Buelga C, Cázares-Körner A, Sanjiv K, Hanna BMF, Mortusewicz O, Rajagopal V, Albers JJ, Hagey DW, Bekkhus T, Eshtad S, Baquero JM, Masuyer G, Wallner O, Müller S, Pham T, Göktürk C, Rasti A, Suman S, Torres-Ruiz R, Sarno A, Wiita E, Homan EJ, Karsten S, Marimuthu K, Michel M, Koolmeister T, Scobie M, Loseva O, Almlöf I, Unterlass JE, Pettke A, Boström J, Pandey M, Gad H, Herr P, Jemth AS, El Andaloussi S, Kalderén C, Rodriguez-Perales S, Benítez J, Krokan HE, Altun M, Stenmark P, Berglund UW, Helleday T. Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Res. 2020 Dec 2;48(21):12234-12251. doi: 10.1093/nar/gkaa1048. PMID: 33211885; PMCID: PMC7708037.
• P, Boström J, Rullman E, Rudd SG, Vesterlund M,  Lehtiö J, Helleday T, Maddalo G,  Altun M. (2020), Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics., Molecular & cellular proteomics: MCP (608-623). PMID: 32051232
• Zhang SM,  Desroses M,  Hagenkort A,  Altun M. et al., (2020). Development of a chemical probe against NUDT15., Nature chemical biology 2020 (1120-1128). PMID: 32690945

Brisken Cathrin

• Aouad P, Zhang Y, De Martino F, Stibolt C, Ali S, Ambrosini G, Mani SA, Maggs K, Quinn HM, Sflomos G, Brisken C. Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nat Commun. 2022 Aug 25;13(1):4975. doi: 10.1038/s41467-022-32523-6. PMID: 36008376; PMCID: PMC9411634.  
• Staaf J, Häkkinen J, Hegardt C, Saal LH, Kimbung S, Hedenfalk I, Lien T, Sørlie T, Naume B, Russnes H, Marcone R, Ayyanan A, Brisken C, Malterling RR, Asking B, Olofsson H, Lindman H, Bendahl PO, Ehinger A, Larsson C, Loman N, Rydén L, Malmberg M, Borg Å, Vallon-Christersson J. RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer. NPJ Breast Cancer. 2022 Aug 16;8(1):94. doi: 10.1038/s41523-022-00465-3. PMID: 35974007; PMCID: PMC9381586.
• Scabia, V., Ayyanan, A., De Martino, F. et al. Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor. Nat Commun 13, 3127 (2022). https://doi.org/10.1038/s41467-022-30898-0
  Press coverage -> https://www.nature.com/articles/s41467-022-30898-0#citeas
• Sflomos G, Schipper K, Koorman T, Fitzpatrick A, Oesterreich S, Lee AV, Jonkers J, Brunton VG, Christgen M, Isacke C, Derksen PWB, Brisken C. Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions. Cancers (Basel). 2021 Oct 27;13(21):5396. doi: 10.3390/cancers13215396. PMID: 34771558; PMCID: PMC8582475.
• Shamseddin M, De Martino F, Constantin C, Scabia V, Lancelot AS, Laszlo C, Ayyannan A, Battista L, Raffoul W, Gailloud-Matthieu MC, Bucher P, Fiche M, Ambrosini G, Sflomos G, Brisken C. Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation. EMBO Mol Med. 2021 Jul 7;13(7):e14314. doi: 10.15252/emmm.202114314. Epub 2021 May 27. PMID: 34042278; PMCID: PMC8261488.
• Sflomos G, Battista L, Aouad P, De Martino F, Scabia V, Stravodimou A, Ayyanan A, Ifticene-Treboux A; RLS, Bucher P, Fiche M, Ambrosini G, Brisken C. Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1. EMBO Mol Med. 2021 Mar 5;13(3):e13180. doi: 10.15252/emmm.202013180. Epub 2021 Feb 22. PMID: 33616307; PMCID: PMC7933935.
• Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D’Santos C, Zwart W, Russell A, Brisken C, Carroll JS. IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis. Cancer Cell. 2020 Sep 14;38(3):412-423.e9. doi: 10.1016/j.ccell.2020.06.007. Epub 2020 Jul 16. PMID: 32679107; PMCID: PMC7116707.
• Cartaxo, AL., Estrada, M., Domenici, G., Roque, R., Silva, F., Gualda, EJ., Loza-Alvarez, P.,  Sflomos, G., and Brisken, C. , Alves, PM., André, S., Brito, C., (2020). A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures. J Exp Clin Cancer Res (S1535-6108(20)30311-1.). doi: 10.1186/s13046-020-01653-4
• Siersbæk, R., Scabia, V., Chernukhin, I., Papachristou, E.,  Broome, R., Green, A.,  Joosten, S., Kumar, S., Alvarez, R., Nagarajan, S., Glont, S., Omarjee S., Aitken, S., Kishore,K., Rakha, E., D’Santos, C., Zwart, W., Russell, A., Brisken, C, Carroll. (2020), IL6/STAT3 co-opts ER regulatory elements to drive metastasis in breast cancer. Cancer Cell. 2020 Jul 6:S1535-6108(20)30311-1. doi: 10.1016/j.ccell.2020.06.007.
• Ataca, D.^*, Aouad, P.^*, Constantin, C.^*, Laszlo, C. F., Beleut, M., Shamseddin M., Rajaram, R. D., Jeitziner, R., Mead, T.J., Caikovski, M., Bucher, P., Ambrosini G., Apte, S.S., Brisken, C. (2020). The secreted protease Adamts18 links mammary epithelial hormone action to extracellular matrix changes and stem cell niche function. Nat Commun. (11(1):1571). doi: 10.1038/s41467-020-15357-y.
• Gagniac, L., Rusidze, M., Boudou, F., Cagnet, S., Adlanmerini, Jeannot, P., M., Weyl, F., Boudou, A., Raymond-Letron, I., Besson, A., Arnal, JF, Brisken, C., Lenfant, F. (2020)., Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium. Development (147(5)),. doi: 10.1242/dev.182303 pii: dev182303
• Brisken C, Scabia V. (2020)., Progesterone receptor signalling in the normal breast and its implications for cancer. J Mol Endocrinol. pii: JME-20-0091.R1. doi: 10.1530/JME-20-0091

Chiorino Giovanna

• Marconi S, Croce M, Chiorino G, Rossi G, Guana F, Profumo A, Ostano P, Alama A, Longo L, De Luca G, Dono M, Dal Bello MG, Ponassi M, Rosano C, Romano P, Cavalieri Z, Grassi M, Tagliamento M, Zullo L, Venturi C, Dellepiane C, Mastracci L, Bennicelli E, Pronzato P, Genova C, Coco S. A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients. Cancers (Basel). 2022 Jul 14;14(14):3412. doi: 10.3390/cancers14143412. PMID: 35884472; PMCID: PMC9317031.
• Sehovic E, Urru S, Chiorino G, Doebler P. Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection. BMC Cancer. 2022 Jun 9;22(1):634. doi: 10.1186/s12885-022-09698-8. PMID: 35681127; PMCID: PMC9178880.
• Akhouayri L, Regragui M, Benayad S, Guebessi NB, Marnissi F, Chiorino G, Karkouri M. Ki-67 proliferation index to further stratify invasive breast cancer molecular subtypes: Northern African comparative cohort-study with external TCGA-BRCA and METABRIC validation. Pan Afr Med J. 2022 Mar 2;41:170. doi: 10.11604/pamj.2022.41.170.31239. PMID: 35655690; PMCID: PMC9120749.
• Chrysanthou E, Sehovic E, Ostano P, Chiorino G. Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples. Cells. 2022 Mar 24;11(7):1099. doi: 10.3390/cells11071099. PMID: 35406661; PMCID: PMC8997401.
• Dinami R, Petti E, Porru M, Rizzo A, Ganci F, Sacconi A, Ostano P, Chiorino G, Trusolino L, Blandino G, Ciliberto G, Zizza P, Biroccio A. TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer. Cancer Lett. 2022 May 1;533:215607. doi: 10.1016/j.canlet.2022.215607. Epub 2022 Feb 28. PMID: 35240232.
• Anastasia A, Dellavedova G, Ramos-Montoya A, James N, Chiorino G, Russo M, Baakza H, Wilson J, Ghilardi C, Cadogan EB, Giavazzi R, Bani MR. The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases. Mol Cancer Ther. 2022 Apr 1;21(4):555-567. doi: 10.1158/1535-7163.MCT-21-0420. PMID: 35149547.
• Ghilardi C, Moreira-Barbosa C, Brunelli L, Ostano P, Panini N, Lupi M, Anastasia A, Fiordaliso F, Salio M, Formenti L, Russo M, Arrigoni E, Chiaradonna F, Chiorino G, Draetta G, Marszalek JR, Vellano CP, Pastorelli R, Bani M, Decio A, Giavazzi R. PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer. Cancer Res. 2022 Apr 1;82(7):1423-1434. doi: 10.1158/0008-5472.CAN-21-1223. PMID: 35131872.
• Mello-Grand M, Bruno A, Sacchetto L, Cristoni S, Gregnanin I, Dematteis A, Zitella A, Gontero P, Peraldo-Neia C, Ricotta R, Noonan DM, Albini A, Chiorino G. Two Novel Ceramide-Like Molecules and miR-5100 Levels as Biomarkers Improve Prediction of Prostate Cancer in Gray-Zone PSA. Front Oncol. 2021 Nov 19;11:769158. doi: 10.3389/fonc.2021.769158. PMID: 34868998; PMCID: PMC8640468.
• Zoma M, Curti L, Shinde D, Albino D, Mitra A, Sgrignani J, Mapelli SN, Sandrini G, Civenni G, Merulla J, Chiorino G, Kunderfranco P, Cacciatore A, Kokanovic A, Rinaldi A, Cavalli A, Catapano CV, Carbone GM. EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer. Nat Commun. 2021 Jul 6;12(1):4147. doi: 10.1038/s41467-021-24380-6. PMID: 34230470; PMCID: PMC8260656.
• Nobili S, Mannini A, Parenti A, Raggi C, Lapucci A, Chiorino G, Paccosi S, Di Gennaro P, Vezzosi V, Romagnoli P, Susini T, Coronnello M. Establishment and characterization of a new spontaneously immortalized ER^–/PR^–/HER2⁺ human breast cancer cell line, DHSF-BR16. Sci Rep. 2021 Apr 16;11(1):8340. doi: 10.1038/s41598-021-87362-0. PMID: 33863935; PMCID: PMC8052418.
• Sulsenti R, Frossi B, Bongiovanni L, Cancila V, Ostano P, Fischetti I, Enriquez C, Guana F, Chiorino G, Tripodo C, Pucillo CE, Colombo MP, Jachetti E. Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma. Front Immunol. 2021 Mar 2;12:622001. doi: 10.3389/fimmu.2021.622001. PMID: 33737929; PMCID: PMC7960782.
• Nanni S, Aiello A, Salis C, Re A, Cencioni C, Bacci L, Pierconti F, Pinto F, Ripoli C, Ostano P, Baroni S, Lazzarino G, Tavazzi B, Pugliese D, Bassi P, Grassi C, Panunzi S, Chiorino G, Pontecorvi A, Gaetano C, Farsetti A. Metabolic Reprogramming by Malat1 Depletion in Prostate Cancer. Cancers (Basel). 2020 Dec 22;13(1):15. doi: 10.3390/cancers13010015. PMID: 33375130; PMCID: PMC7801945.
• Patel A, Garcia LF, Mannella V, Gammon L, Borg TM, Maffucci T, Scatolini M, Chiorino G, Vergani E, Rodolfo M, Maurichi A, Posch C, Matin RN, Harwood CA, Bergamaschi D., (2020). Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma. Cancer Res (80(12):2676-2688). PMID: 32291316 doi: 10.1158/0008-5472.CAN-19-3230
• Peraldo-Neia C, Ostano P, Mello-Grand M, Guana F, Gregnanin I, Boschi D, Oliaro-Bosso S, Pippione AC, Carenzo A, De Cecco L, Cavalieri S, Micali A, Perrone F, Averono G, Bagnasacco P, Dosdegani R, Masini L, Krengli M, Aluffi-Valletti P, Valente G, Chiorino G. AKR1C3 is a biomarker and druggable target for oropharyngeal tumors. Cell Oncol (Dordr). 2020 Nov 19. doi: 10.1007/s13402-020-00571-z. Epub ahead of print. PMID: 33211282.
• Scatolini, M., Patel, A., Grosso, E., Mello-Grand, M., Ostano, P., Coppo, R., Vitiello, M., Venesio, T., Zaccagna, A., Pisacane, A., Sarotto, I., Taverna, D., Poliseno, L., Bergamaschi, D., & Chiorino, G. GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma. doi: https://doi.org/10.1111/bjd.20629

De Clerq Wim

• de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J. ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. Nature. 2022 Jul;607(7920):784-789. doi: 10.1038/s41586-022-04974-w. Epub 2022 Jul 20. PMID: 35859175.
• Timmermans S, Verhoog NJD, Van Looveren K, Dewaele S, Hochepied T, Eggermont M, Gilbert B, Boerema-de Munck A, Vanderhaeghen T, Vanden Berghe J, Garcia Gonzalez N, Vandewalle J, Bloch Y, Provost M, Savvides SN, De Bosscher K, Declercq W, Rottier RJ, Louw A, Libert C. Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding. J Biol Chem. 2022 Feb;298(2):101574. doi: 10.1016/j.jbc.2022.101574. Epub 2022 Jan 8. PMID: 35007536; PMCID: PMC8808175.
• De Schutter E, Ramon J, Pfeuty B, De Tender C, Stremersch S, Raemdonck K, de Beeck KO, Declercq W, Riquet FB, Braeckmans K, Vandenabeele P. Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis. Cell Mol Life Sci. 2021 Dec 31;79(1):19. doi: 10.1007/s00018-021-04078-0. PMID: 34971436; PMCID: PMC8720079.
• Sipieter F, Cappe B, Leray A, De Schutter E, Bridelance J, Hulpiau P, Van Camp G, Declercq W, Héliot L, Vincent P, Vandenabeele P, Riquet FB. Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis. iScience. 2021 Sep 2;24(9):103074. doi: 10.1016/j.isci.2021.103074. PMID: 34568795; PMCID: PMC8449238.
• Teufelberger AR, Van Nevel S, Hulpiau P, Nordengrün M, Savvides SN, De Graeve S, Akula S, Holtappels G, De Ruyck N, Declercq W, Vandenabeele P, Hellman L, Bröker BM, Krysko DV, Bachert C, Krysko O. Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33. Front Immunol. 2020 Sep 25;11:582044. doi: 10.3389/fimmu.2020.582044. PMID: 33072128; PMCID: PMC7544847.
• Aaes TL, Verschuere H, Kaczmarek A, Heyndrickx L, Wiernicki B, Delrue I, De Craene B, Taminau J, Delvaeye T, Bertrand MJM, Declercq W, Berx G, Krysko DV, Adjemian S, Vandenabeele P. Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection. J Immunol. 2020 Feb 15;204(4):775-787. doi: 10.4049/jimmunol.1900072. Epub 2020 Jan 3. PMID: 31900335.
• Devos M, Tanghe G, Gilbert B, Dierick E, Verheirstraeten M, Nemegeer J, de Reuver R, Lefebvre S, De Munck J, Rehwinkel J, Vandenabeele P, Declercq W, Maelfait J. Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation. J Exp Med. 2020 Jul 6;217(7):e20191913. doi: 10.1084/jem.20191913. PMID: 32315377; PMCID: PMC7336309.
• Hoste E, Maueröder C, van Hove L, Catrysse L, Vikkula HK, Sze M, Maes B, Karjosukarso D, Martens L, Gonçalves A, Parthoens E, Roelandt R, Declercq W, Fuentes I, Palisson F, Gonzalez S, Salas-Alanis JC, Boon L, Huebener P, Mulder KW, Ravichandran K, Saeys Y, Schwabe RF, van Loo G. Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation. Cell Rep. 2019 Nov 26;29(9):2689-2701.e4. doi: 10.1016/j.celrep.2019.10.104. PMID: 31775038.
• Konieczny P, Lichawska-Cieslar A, Kwiecinska P, Cichy J, Pietrzycka R, Szukala W, Declercq W, Devos M, Paziewska A, Rumienczyk I, Kulecka M, Mikula M, Fu M, Borowczyk J, Santamaria-Babí LF, Jura J. Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation. J Mol Med (Berl). 2019 Dec;97(12):1669-1684. doi: 10.1007/s00109-019-01853-2. Epub 2019 Nov 30. PMID: 31786670.
• Lichawska-Cieslar A, Konieczny P, Szukala W, Declercq W, Fu M, Jura J. Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118866. doi: 10.1016/j.bbamcr.2020.118866. Epub 2020 Sep 29. PMID: 33007332.
• Martens S, Hofmans S, Declercq W, Augustyns K, Vandenabeele P. Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs. Trends Pharmacol Sci. 2020 Mar;41(3):209-224. doi: 10.1016/j.tips.2020.01.002. Epub 2020 Feb 5. PMID: 32035657.

Dotto Gian Paolo

• Koliaraki V, Dotto GP, Buckley CD, Kollias G. Mesenchymal cells in health and disease. Nat Immunol. 2022 Oct;23(10):1395-1398. doi: 10.1038/s41590-022-01318-8. PMID: 36163467.
• Capolupo L, Khven I, Lederer AR, Mazzeo L, Glousker G, Ho S, Russo F, Montoya JP, Bhandari DR, Bowman AP, Ellis SR, Guiet R, Burri O, Detzner J, Muthing J, Homicsko K, Kuonen F, Gilliet M, Spengler B, Heeren RMA, Dotto GP, La Manno G, D’Angelo G. Sphingolipids control dermal fibroblast heterogeneity. Science. 2022 Apr 15;376(6590):eabh1623. doi: 10.1126/science.abh1623. Epub 2022 Apr 15. PMID: 35420948.
• Xu X, Tassone B, Ostano P, Katarkar A, Proust T, Joseph JM, Riganti C, Chiorino G, Kutalik Z, Lefort K, Dotto GP. HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations. EMBO Mol Med. 2021 Jul 7;13(7):e14133. doi: 10.15252/emmm.202114133. Epub 2021 Jun 29. PMID: 34185380; PMCID: PMC8261506.
• Dotto GP, Missero C. Flash forward genetics: new twists in transcription across evolutionary boundaries. EMBO Rep. 2021 Mar 3;22(3):e52152. doi: 10.15252/embr.202052152. Epub 2021 Feb 8. PMID: 33554445; PMCID: PMC7926253.
• Zhou Q, Kim SH, Pérez-Lorenzo R, Liu C, Huang M, Dotto GP, Zheng B, Wu X. Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway. J Invest Dermatol. 2021 Jan;141(1):152-163. doi: 10.1016/j.jid.2020.05.114. Epub 2020 Jun 30. PMID: 32619504; PMCID: PMC8179313.
• Dotto GP, Missero C. Flash forward genetics: new twists in transcription across evolutionary boundaries. EMBO Rep. 2021 Mar 3;22(3):e52152. doi: 10.15252/embr.202052152. Epub 2021 Feb 8. PMID: 33554445; PMCID: PMC7926253.
• Ma M, Bordignon P, Dotto GP, Pelet S. Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors. Heliyon. 2020 Dec 7;6(12):e05574. doi: 10.1016/j.heliyon.2020.e05574. PMID: 33319088; PMCID: PMC7723811.
• Katarkar, A., Bottoni, G., Clocchiatti, A., Goruppi, S., Bordignon, P., Lazzaroni^, F., Gregnanin, I., Ostano, P., Neel,V., and G.P. Dotto (2020) NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin. Nature Comm. 2020. doi:10.1038/s41467-020-18919-2  For highlights click here
• Ma, M., Ghosh,S., Tavernari, D., Katarkar, A., Clocchiatti, A., Mazzeo,L., Samarkina, A., Epiney, Yu, Y._R. Ho, P.-C., Levesque, M.P. Özdemir, B.C., Ciriello, G., Dummer, R. and G.P. Dotto(2020) Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis. J. Exp. Med. 2020 e20201137. Doi : doi.org/10.1084/jem.20201137 

Kaprio Jaakko

• Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M. Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer. Twin Res Hum Genet. 2022 Sep 8:1-9. doi: 10.1017/thg.2022.32. Epub ahead of print. PMID: 36073160.
• Silventoinen K, Piirtola M, Jelenkovic A, Sund R, Tarnoki AD, Tarnoki DL, Medda E, Nisticò L, Toccaceli V, Honda C, Inui F, Tomizawa R, Watanabe M, Sakai N, Gatz M, Butler DA, Lee J, Lee SJ, Sung J, Franz CE, Kremen WS, Lyons MJ, Derom CA, Vlietinck RF, Loos RJF, Tynelius P, Rasmussen F, Martin NG, Medland SE, Montgomery GW, Brandt I, Nilsen TS, Harris JR, Tyler J, Hopper JL, Magnusson PKE, Pedersen NL, Dahl Aslan AK, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Rebato E, Zhang D, Pang Z, Tan Q, Silberg JL, Maes HH, Boomsma DI, Sørensen TIA, Korhonen T, Kaprio J. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. Sci Rep. 2022 Jul 31;12(1):13148. doi: 10.1038/s41598-022-17536-x. PMID: 35909142; PMCID: PMC9339539.
• Korhonen T, Hjelmborg J, Harris JR, Clemmensen S, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) collaboration. Cancer in twin pairs discordant for smoking: The Nordic Twin Study of Cancer. Int J Cancer. 2022 Jul 1;151(1):33-43. doi: 10.1002/ijc.33963. Epub 2022 Feb 24. PMID: 35143046; PMCID: PMC9304125.
• Wang J, Conti DV, Epeldegui M, Ollikainen M, Tyndale RF, Hwang AE, Magpantay L, Mack TM, Martinez-Maza O, Kaprio J, Cozen W. Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking. Cancers (Basel). 2021 Oct 27;13(21):5395. doi: 10.3390/cancers13215395. PMID: 34771561; PMCID: PMC8582438.
• Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, …, Kaprio J, et al. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet. 2021 Sep;53(9):1311-1321. doi: 10.1038/s41588-021-00923-x. Epub 2021 Sep 6. PMID: 34493871; PMCID: PMC7612069.
• Clemmensen SB, Harris JR, Mengel-From J, Bonat WH, Frederiksen H, Kaprio J, Hjelmborg JVB. Familial Risk and Heritability of Hematologic Malignancies in the Nordic Twin Study of Cancer. Cancers (Basel). 2021 Jun 16;13(12):3023. doi: 10.3390/cancers13123023. PMID: 34208754; PMCID: PMC8234145.
• Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, Arp PP, Broer L, Buxton JL, Da Silva Couto Alves A, …, Kaprio J, et al. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020 Mar 5;106(3):389-404. doi: 10.1016/j.ajhg.2020.02.006. Epub 2020 Feb 27. PMID: 32109421; PMCID: PMC7058826.
• Mars N, Widén E, Kerminen S, Meretoja T, Pirinen M, Della Briotta Parolo P, Palta P; FinnGen, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nat Commun. 2020 Dec 14;11(1):6383. doi: 10.1038/s41467-020-19966-5. PMID: 33318493.
• Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB. Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Nat Commun. 2020 Nov 3;11(1):5562. doi: 10.1038/s41467-020-19265-z. PMID: 33144568; PMCID: PMC7642344.
• Brumpton B, Sanderson E, Heilbron K, Hartwig FP, Harrison S, Vie GÅ, Cho Y, Howe LD, Hughes A, Boomsma DI, Havdahl A, Hopper J, Neale M, Nivard MG, Pedersen NL, Reynolds CA, Tucker-Drob EM, Grotzinger A, Howe L, Morris T, Li S; Within-family Consortium; 23andMe Research Team, Auton A, Windmeijer F, Chen WM, Bjørngaard JH, Hveem K, Willer C, Evans DM, Kaprio J, Davey Smith G, Åsvold BO, Hemani G, Davies NM. Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nat Commun. 2020 Jul 14;11(1):3519. doi: 10.1038/s41467-020-17117-4. PMID: 32665587; PMCID: PMC7360778.
• García-González J, Brock AJ, Parker MO, Riley RJ, Joliffe D, Sudwarts A, Teh MT, Busch-Nentwich EM, Stemple DL, Martineau AR, Kaprio J, Palviainen T, Kuan V, Walton RT, Brennan CH. Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. Elife. 2020 Mar 25;9:e51295. doi: 10.7554/eLife.51295. PMID: 32209227; PMCID: PMC7096180.

Hess Kathryn

• Colombo G, Cubero RJA, Kanari L, Venturino A, Schulz R, Scolamiero M, Agerberg J, Mathys H, Tsai LH, Chachólski W, Hess K, Siegert S. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes. Nat Neurosci. 2022 Oct;25(10):1379-1393. doi: 10.1038/s41593-022-01167-6. Epub 2022 Sep 30. PMID: 36180790; PMCID: PMC9534764.
• Hess KA, Pariyadath A, Sanchez TM, Shojaee S. An Unexpected Journey of a Loose Screw. J Bronchology Interv Pulmonol. 2022 Oct 1;29(4):e65-e67. doi: 10.1097/LBR.0000000000000831. Epub 2022 Jul 13. PMID: 35822737.
• Jiao W, Spreemann G, Ruchti E, Banerjee S, Vernon S, Shi Y, Stowers RS, Hess K, McCabe BD. Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism. Elife. 2022 Jul 8;11:e74968. doi: 10.7554/eLife.74968. PMID: 35801638; PMCID: PMC9270032.
• Kanari L, Dictus H, Chalimourda A, Arnaudon A, Van Geit W, Coste B, Shillcock J, Hess K, Markram H. Computational synthesis of cortical dendritic morphologies. Cell Rep. 2022 Apr 5;39(1):110586. doi: 10.1016/j.celrep.2022.110586. PMID: 35385736.
• Zisis E, Keller D, Kanari L, Arnaudon A, Gevaert M, Delemontex T, Coste B, Foni A, Abdellah M, Calì C, Hess K, Magistretti PJ, Schürmann F, Markram H. Digital Reconstruction of the Neuro-Glia-Vascular Architecture. Cereb Cortex. 2021 Oct 22;31(12):5686-5703. doi: 10.1093/cercor/bhab254. PMID: 34387659; PMCID: PMC8568010.
• Hess K. (2020) Topological Adventures in Neuroscience. In: Baas N., Carlsson G., Quick G., Szymik M., Thaule M. (eds) Topological Data Analysis. Abel Symposia, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-030-43408-3_11
• Fournier M, Scolamiero M, Gholam-Rezaee MM, Cleusix M, Jenni R, Ferrari C, Golay P, Baumann PS, Cuenod M, Conus P, Do KQ, Hess K. Topology predicts long-term functional outcome in early psychosis. Mol Psychiatry. 2020 Jul 6. doi: 10.1038/s41380-020-0826-1. Epub ahead of print. PMID: 32632207.

Kasper Maria

• Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J. Retrograde movements determine effective stem cell numbers in the intestine. Nature. 2022 Jul;607(7919):548-554. doi: 10.1038/s41586-022-04962-0. Epub 2022 Jul 13. PMID: 35831497.
• Hoste E, Lecomte K, Annusver K, Vandamme N, Roels J, Maschalidi S, Verboom L, Vikkula HK, Sze M, Van Hove L, Verstaen K, Martens A, Hochepied T, Saeys Y, Ravichandran K, Kasper M, van Loo G. OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity. Nat Commun. 2021 Oct 8;12(1):5913. doi: 10.1038/s41467-021-25944-2. PMID: 34625556; PMCID: PMC8501048.
• Larsson AJM, Ziegenhain C, Hagemann-Jensen M, Reinius B, Jacob T, Dalessandri T, Hendriks GJ, Kasper M, Sandberg R. Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance. PLoS Comput Biol. 2021 Mar 9;17(3):e1008772. doi: 10.1371/journal.pcbi.1008772. PMID: 33690599; PMCID: PMC7978379.
• Lichtenberger BM, Kasper M. Cellular heterogeneity and microenvironmental control of skin cancer. Journal of Internal Medicine. 2020 Sep. DOI: 10.1111/joim.13177.
• Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R, Kasper M. The Molecular Anatomy of Mouse Skin during Hair Growth and Rest. Cell Stem Cell. 2020 Mar 5;26(3):441-457.e7. doi: 10.1016/j.stem.2020.01.012. Epub 2020 Feb 27. PMID: 32109378.
• Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Füllgrabe A, Gerling M, Kasper M. Coordinated hedgehog signaling induces new hair follicles in adult skin. Elife. 2020 Mar 17;9:e46756. doi: 10.7554/eLife.46756. PMID: 32178760; PMCID: PMC7077985.
• Zhang Y, Annusver K, Sunadome K, Kameneva P, Edwards S, Lei G, Kasper M, Chagin AS, Adameyko I, Xie M. Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis. Front Cell Dev Biol. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122. PMID: 32211405; PMCID: PMC7066500.
• Norum JH, Frings O, Kasper M, Bergholtz H, Zell Thime H, Bergström Å, Andersson A, Kuiper R, Fredlund E, Sørlie T, Toftgård R. GLI1-induced mammary gland tumours are transplantable and maintain major molecular features. Int J Cancer. 2020 Feb 15;146(4):1125-1138. doi: 10.1002/ijc.32522. Epub 2019 Jul 8. PMID: 31219615.

Verschuren Emmy

• Talwelkar SS, Lähdeniemi IAK, Mäyränpää MI, Hemmes A, Linnavirta N, Räsänen J, Knuuttila A, Wennerberg K, Verschuren EW. Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics. STAR Protoc. 2022 Sep 26;3(4):101720. doi: 10.1016/j.xpro.2022.101720. Epub ahead of print. PMID: 36170112; PMCID: PMC9520273.
• Gao Y, Päivinen P, Tripathi S, Domènech-Moreno E, Wong IPL, Vaahtomeri K, Nagaraj AS, Talwelkar SS, Foretz M, Verschuren EW, Viollet B, Yan Y, Mäkelä TP. Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma. Clin Cancer Res. 2022 Jan 1;28(1):227-237. doi: 10.1158/1078-0432.CCR-21-2049. Epub 2021 Oct 19. PMID: 34667030.
• Bao J, Närhi K, Teodòsio A, Hemmes A, Linnavirta NM, Mäyränpää MI, Salmenkivi K, Le Quesne J, Verschuren EW. SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes. J Pathol. 2021 Sep;255(1):16-29. doi: 10.1002/path.5733. Epub 2021 Jun 19. PMID: 34021911.
• Tervonen TA, Pant SM, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin. Cancer Res. 2021 Mar 15;81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760. Epub 2021 Jan 18. PMID: 33461973.
• Talwelkar,S., Mäyränpää, M., Søraas, L., Potdar, S., Bao, J,, Hemmes,A., Linnavirta, N., Lømo, J, Räsänen,J,, Knuuttila, A, Wennerberg,K. Verschuren, EW. Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments. doi: https://doi.org/10.1016/j.xcrm.2021.100373

Wagner Erwin

• Mellor LF, Gago-Lopez N, Bakiri L, Schmidt FN, Busse B, Rauber S, Jimenez M, Megías D, Oterino-Soto S, Sanchez-Prieto R, Grivennikov S, Pu X, Oxford J, Ramming A, Schett G, Wagner EF. Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease. Ann Rheum Dis. 2022 Jul 4;81(10):1400–8. doi: 10.1136/annrheumdis-2022-222229. Epub ahead of print. PMID: 35788494; PMCID: PMC9484400.
• Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, Schauer S, Baumgartner VJ, Grabner GF, Schabbauer G, Wolinski H, Robertson GR, Hoefler G, Zeng W, Wagner EF, Schweiger M, Zechner R. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112840119. doi: 10.1073/pnas.2112840119. PMID: 35210363; PMCID: PMC8892347.
• Petruzzelli M, Ferrer M, Schuijs MJ, Kleeman SO, Mourikis N, Hall Z, Perera D, Raghunathan S, Vacca M, Gaude E, Lukey MJ, Jodrell DI, Frezza C, Wagner EF, Venkitaraman AR, Halim TYF, Janowitz T. Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia. Cancers (Basel). 2022 Feb 15;14(4):963. doi: 10.3390/cancers14040963. PMID: 35205709; PMCID: PMC8870098.
• Blair L, Pattison MJ, Chakravarty P, Papoutsopoulou S, Bakiri L, Wagner EF, Smale S, Ley SC. TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages. J Immunol. 2022 Feb 15;208(4):941-954. doi: 10.4049/jimmunol.2100213. Epub 2022 Jan 26. PMID: 35082159; PMCID: PMC9012084.
• Riedel M, Cai H, Stoltze IC, Vendelbo MH, Wagner EF, Bakiri L, Thomsen MK. Targeting AP-1 transcription factors by CRISPR in the prostate. Oncotarget. 2021 Sep 14;12(19):1956-1961. doi: 10.18632/oncotarget.27997. PMID: 34548912; PMCID: PMC8448511.
• Peters F, Rahn S, Mengel M, Scharfenberg F, Otte A, Koudelka T, Wagner EF, Wunderlich FT, Haase M, Naumann R, Tholey A, Becker-Pauly C. Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis. Matrix Biol. 2021 Aug;102:37-69. doi: 10.1016/j.matbio.2021.08.002. Epub 2021 Sep 8. Erratum in: Matrix Biol. 2021 Nov 2;: PMID: 34508852.
• Marques C, Unterkircher T, Kroon P, Oldrini B, Izzo A, Dramaretska Y, Ferrarese R, Kling E, Schnell O, Nelander S, Wagner EF, Bakiri L, Gargiulo G, Carro MS, Squatrito M. NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1. Elife. 2021 Aug 17;10:e64846. doi: 10.7554/eLife.64846. PMID: 34399888; PMCID: PMC8370767.
• Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE. Calprotectin: from biomarker to biological function. Gut. 2021 Oct;70(10):1978-1988. doi: 10.1136/gutjnl-2021-324855. Epub 2021 Jun 18. PMID: 34145045; PMCID: PMC8458070.
• Fan F, Malvestiti S, Vallet S, Lind J, Garcia-Manteiga JM, Morelli E, Jiang Q, Seckinger A, Hose D, Goldschmidt H, Stadlbauer A, Sun C, Mei H, Pecherstorfer M, Bakiri L, Wagner EF, Tonon G, Sattler M, Hu Y, Tassone P, Jaeger D, Podar K. JunB is a key regulator of multiple myeloma bone marrow angiogenesis. Leukemia. 2021 Dec;35(12):3509-3525. doi: 10.1038/s41375-021-01271-9. Epub 2021 May 18. Erratum in: Leukemia. 2021 Sep 6;: PMID: 34007044; PMCID: PMC8632680.
• Gago-López N, Lagunas Arnal C, Perez JJ, Wagner EF. Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model. Exp Dermatol. 2021 Nov;30(11):1662-1674. doi: 10.1111/exd.14390. Epub 2021 May 28. PMID: 33998705; PMCID: PMC8597152.
• Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M. Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells. doi: https://doi.org/10.15252/emmm.202012409
• Philipp Novoszel , Barbara Drobits  , Martin Holcmann   , Cristiano De Sa Fernandes   , Roland Tschismarov   , Sophia Derdak, Thomas Decker   , Erwin F Wagner  , Maria Sibilia. The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity. doi: https://doi.org/10.1038/s41418-021-00765-4 
• Sukseree S, Bakiri L, Palomo-Irigoyen M, Uluçkan Ö, Petzelbauer P, Wagner EF. Sequestosome 1/p62 enhances chronic skin inflammation. J Allergy Clin Immunol. 2021 Jun;147(6):2386-2393.e4. doi: 10.1016/j.jaci.2021.02.028. Epub 2021 Mar 4. PMID: 33675820.
• Riedel M, Berthelsen MF, Cai H, Haldrup J, Borre M, Paludan SR, Hager H, Vendelbo MH, Wagner EF, Bakiri L, Thomsen MK. In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun. Oncogene. 2021 Apr;40(13):2437-2447. doi: 10.1038/s41388-021-01724-6. Epub 2021 Mar 5. PMID: 33674748; PMCID: PMC7610543.
• Carbó JM, León TE, Font-Díaz J, De la Rosa JV, Castrillo A, Picard FR, Staudenraus D, Huber M, Cedó L, Escolà-Gil JC, Campos L, Bakiri L, Wagner EF, Caelles C, Stratmann T, Van Ginderachter JA, Valledor AF. Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. Cancer Res. 2021 Feb 15;81(4):968-985. doi: 10.1158/0008-5472.CAN-19-3360. Epub 2020 Dec 23. PMID: 33361391.
• Matsuoka K, Bakiri L, Wolff LI, Linder M, Mikels-Vigdal A, Patiño-García A, Lecanda F, Hartmann C, Sibilia M, Wagner EF. Wnt signaling and Loxl2 promote aggressive osteosarcoma. Cell Res. 2020 Oct;30(10):885-901. doi: 10.1038/s41422-020-0370-1. Epub 2020 Jul 20. PMID: 32686768; PMCID: PMC7608146.