16.00-19.30 Swiss Time (11 am -2 pm East Coast US; 8-11 am West Coast US) 



16:00-16:10               Introductory remarks and overview



Gian Paolo Dotto 



SESSION 1 – Gender medicine, sex determination and cancer susceptibility



16:10-16:35.          Ongoing efforts in gender medicine



Sabine Oertelt-Prigione



Professor of Gender in Primary and Transmural Care, Radboud University , Nijmegen, The Netherlands



16:35-17:00            Sex differences in epidemiology of non-sex related cancers



 Melinda Schuurman



Netherlands Cancer Registry, M.Schuurman@iknl.nland j.praagman@IKNL.NL



17:00-17:25             Sex differences in response to anticancer drugs and immune therapy 



 Anna Dorothea Wagner and Berna Özdemir



Consultant Department of Oncology Lausanne University Hospital CHUV/ Bern University Hospital (Inselspital)



17:25-17:40             Break



17:40-18:00             Beyond dimorphism – Disentangling the science in cancer care for transgender and non-binary people



Dr Alison May Berner



Speciality Trainee and Clinical Research Fellow in Medical Oncology



Barts Cancer Institute&Specialist Registrar in Gender Identity
Gender Identity Clinic, Tavistock and Portman NHS Foundation Trust



18:00-18:25            Genetic basis of sex determination




Head of the Laboratory of Stem Cell Biology and Developmental Genetics at the Francis Crick Institute



18.25 -18:50             The sex of the intestine and why it matters



Irene Miguel-Aliaga



Genes and Metabolism Section Chair, MRC London Institute of Medical Sciences, and Professor of Genetics and Physiology, Imperial College



19:00-20:00            Meet the speakers roundtable.

16:00-19:00 pm Swiss Time (11 am -1:30 pm East Coast US; 8-10:30 am West Coast US)



SESSION 2 – Genetic predisposition and cancer cells genetics



16:00-16:25            Twins, hormones and cancer risk factors



Jaakko Kaprio



Professor of Genetic Epidemiology, Department of Public Health, Faculty of Medicine & Institute for Molecular Medicine FIMM, HiLIFE University of Helsinki



16:25-16:50            Genetic determinants of cancer susceptibility : a look to the future



Allan Balmain



Professor of Cancer Genetics, UCSF



16:50-17:15            X chromosome silencing and biological impact



Jeannie Lee



Professor of Genetics (Pathology), Harvard Medical School, Molecular Biologist, Massachusetts General Hospital



17:15-17:30            Break



17:30-17:55            “Gender specificity in DNA damage response pathways”



Laura Zannini



Group leader, Institute of Molecular Genetics, National Research Council (IGM-CNR), Pavia, IT



17:55–18:20            “The molecular epidemiology of somatic mutations: how does patient sex influence cancer evolution?”



 Paul C. Boutros


Group leader, UCLA



19:00-20:00               Meet the speakers roundtable

16:00-19:00 pm Swiss Time (11 am -2 pm East Coast US; 8-11 am West Coast US )



SESSION 3 – gene mutations and cancer



16:00-16:25            Tumor-suppressor genes that escape from X-inactivation



 Andrew Lane 



Broad Institute of Harvard and MIT, and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, Massachusetts, USA, 



16:25-16:50            Sex disparity and the p53 signaling network



Sue Haupt and Yigal Haupt



Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria 3000,



16:50-17:15              Sex differences in glioblastoma



Joshua B. Rubin



Professor of Pediatrics, Hematology and Oncology, Washington University School of Medicine in St. Louis,



17:15-17:30             Break



17:30-17:55            Pancreatic Cancer



Alexandros Tzatsos



Group leader, School of Medicine and Health Science, George Washington University,



17:55-18:20            Novel Mechanisms of Cancer Emerge When Accounting



                                   for Sex as a Biological Variable



                                   Kenneth Buetow



                                   Professor and CEM Center Director, Arizona State University






18:30-19:30            Meet the speakers roundtable

16:00-19:00 pm Swiss Time (11 am -2 pm East Coast US; 8-11 am West Coast US)



SESSION 4 – Hormones and cancer



16:00- 16:25             Structure/function



Eva Estébanez-Perpina



AR Group leader Institute of Biomedicine of the University of Barcelona (IBUB),



16:25-16:50             Role of local sex steroid synthesis and metabolism in hormonal carcinogenesis



Matti Poutanen



Professor of Physiology, Institute of Biomedicine, University of Turku, Finland



16:50-17:15             Finding Dory: hormone exposure, mutational signatures and estrogen receptor defines the early oncogenesis processes at play in the cell of origin of breast cancer



Luca Magnani



Group leader, Imperial College London,.



17:15-17:30             Break



17:30-17:55            Sex hormones signaling in male breast cancer



Wilbert Zwart



Group leader, Netherlands Cancer Institute (NKI),



17:55-18:20            ER signaling and Melanoma



Todd Ridky



Group leader Department of Dermatology, U. Penn,



18:20-18:45            AR signaling in skin cancer



 Soumitra Ghosh / Min Ma



UNIL, Department of Biochemistry,



18:45-19:00            Break



19:00-20:00            Meet the speakers roundtable

16:00-17:00 pm Swiss Time (11 am -12 pm East Coast US; 8-9 am West Coast US)






16:00-16:25            Gender differences in metabolism



Adriana Maggi



Professor of Pharmacological Biotechnologies, University of Milan,



16:25-16:50             “Gene-by-sex interactions regulating mitochondrial functions and cardio-metabolic traits”



Aldons Jake Lusis






16:50-17:15             “Sex differences in brain development and function: Implications for comorbidity of psychiatric and cardiovascular outcomes”



 Jill Goldstein



Professor of Psychiatry and Medicine, Harvard Medical School; Executive Director, Innovation Center on Sex Differences in Medicine, Massachusetts General



17:15-17:30            Break



17:30-18:00            ICPI life time achievement cancer prevention award



Tony Howell



18:00-18:50            Poster awards (with awardees’ speed talks) 



18:50-19:15            Sexual dimorphism in cancer : meeting overview



Sarah Seton.Rogers



 Chief Editor, Nature Reviews Cancer



19:15 – 19:30          Concluding remarks                                 


 G. Paolo Dotto