16.00-19.30 Swiss Time (11 am -2 pm East Coast US; 8-11 am West Coast US)
16:00-16:10 Introductory remarks and overview
Gian Paolo Dotto
SESSION 1 – Gender medicine, sex determination and cancer susceptibility
16:10-16:35. Ongoing efforts in gender medicine
Sabine Oertelt-Prigione
Professor of Gender in Primary and Transmural Care, Radboud University , Nijmegen, The Netherlands Sabine.Oertelt-Prigione@radboudumc.nl
16:35-17:00 Sex differences in epidemiology of non-sex related cancers
Melinda Schuurman
Netherlands Cancer Registry, M.Schuurman@iknl.nland j.praagman@IKNL.NL
17:00-17:25 Sex differences in response to anticancer drugs and immune therapy
Anna Dorothea Wagner and Berna Özdemir
Consultant Department of Oncology Lausanne University Hospital CHUV/ Bern University Hospital (Inselspital)dorothea.wagner@chuv.chBerna.oezdemir@insel.ch
17:25-17:40 Break
17:40-18:00 Beyond dimorphism – Disentangling the science in cancer care for transgender and non-binary people
Dr Alison May Berner
Speciality Trainee and Clinical Research Fellow in Medical Oncology
Barts Cancer Institute&Specialist Registrar in Gender Identity
Gender Identity Clinic, Tavistock and Portman NHS Foundation Trust
alison.berner@nhs.net
18:00-18:25 Genetic basis of sex determination
Robin.Lovell-Badge
Head of the Laboratory of Stem Cell Biology and Developmental Genetics at the Francis Crick Institute Robin.Lovell-Badge@crick.ac.uk
18.25 -18:50 The sex of the intestine and why it matters
Irene Miguel-Aliaga
Genes and Metabolism Section Chair, MRC London Institute of Medical Sciences, and Professor of Genetics and Physiology, Imperial College i.miguel-aliaga@lms.mrc.ac.uk
19:00-20:00 Meet the speakers roundtable.
16:00-19:00 pm Swiss Time (11 am -1:30 pm East Coast US; 8-10:30 am West Coast US)
SESSION 2 – Genetic predisposition and cancer cells genetics
16:00-16:25 Twins, hormones and cancer risk factors
Jaakko Kaprio
Professor of Genetic Epidemiology, Department of Public Health, Faculty of Medicine & Institute for Molecular Medicine FIMM, HiLIFE University of Helsinki jaakko.kaprio@helsinki.fi
16:25-16:50 Genetic determinants of cancer susceptibility : a look to the future
Allan Balmain
Professor of Cancer Genetics, UCSF allan.Balmain@ucsf.edu
16:50-17:15 X chromosome silencing and biological impact
Jeannie Lee
Professor of Genetics (Pathology), Harvard Medical School, Molecular Biologist, Massachusetts General Hospital lee@molbio.mgh.harvard.edu
17:15-17:30 Break
17:30-17:55 “Gender specificity in DNA damage response pathways”
Laura Zannini
Group leader, Institute of Molecular Genetics, National Research Council (IGM-CNR), Pavia, IT laura.zannini@igm.cnr.it
17:55–18:20 “The molecular epidemiology of somatic mutations: how does patient sex influence cancer evolution?”
Paul C. Boutros
Group leader, UCLA PBoutros@mednet.ucla.edu
19:00-20:00 Meet the speakers roundtable
16:00-19:00 pm Swiss Time (11 am -2 pm East Coast US; 8-11 am West Coast US )
SESSION 3 – gene mutations and cancer
16:00-16:25 Tumor-suppressor genes that escape from X-inactivation
Andrew Lane
Broad Institute of Harvard and MIT, and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, Massachusetts, USA, andrew_lane@dfci.harvard.edu
16:25-16:50 Sex disparity and the p53 signaling network
Sue Haupt and Yigal Haupt
Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria 3000, Australiasue.haupt@petermac.org
16:50-17:15 Sex differences in glioblastoma
Joshua B. Rubin
Professor of Pediatrics, Hematology and Oncology, Washington University School of Medicine in St. Louis, rubin_j@wustl.edu
17:15-17:30 Break
17:30-17:55 Pancreatic Cancer
Alexandros Tzatsos
Group leader, School of Medicine and Health Science, George Washington University, atzatsos@email.gwu.edu
17:55-18:20 Novel Mechanisms of Cancer Emerge When Accounting
for Sex as a Biological Variable
Kenneth Buetow
Professor and CEM Center Director, Arizona State University
Kenneth.Buetow@asu.edu
18:30-19:30 Meet the speakers roundtable
16:00-19:00 pm Swiss Time (11 am -2 pm East Coast US; 8-11 am West Coast US)
SESSION 4 – Hormones and cancer
16:00- 16:25 Structure/function
Eva Estébanez-Perpina
AR Group leader Institute of Biomedicine of the University of Barcelona (IBUB), evaestebanez@ub.edu
16:25-16:50 Role of local sex steroid synthesis and metabolism in hormonal carcinogenesis
Matti Poutanen
Professor of Physiology, Institute of Biomedicine, University of Turku, Finland matpou@utu.fi
16:50-17:15 Finding Dory: hormone exposure, mutational signatures and estrogen receptor defines the early oncogenesis processes at play in the cell of origin of breast cancer
Luca Magnani
Group leader, Imperial College London,. l.magnani@imperial.ac.uk
17:15-17:30 Break
17:30-17:55 Sex hormones signaling in male breast cancer
Wilbert Zwart
Group leader, Netherlands Cancer Institute (NKI),w.zwart@nki.nl
17:55-18:20 ER signaling and Melanoma
Todd Ridky
Group leader Department of Dermatology, U. Penn, ridky@pennmedicine.upenn.edu
18:20-18:45 AR signaling in skin cancer
Soumitra Ghosh / Min Ma
UNIL, Department of Biochemistry, soumitra.ghosh@unil.chmin.ma@unil.ch
18:45-19:00 Break
19:00-20:00 Meet the speakers roundtable
16:00-17:00 pm Swiss Time (11 am -12 pm East Coast US; 8-9 am West Coast US)
SESSION 5 – FRONTIERS AND OPPORTUNITIES
16:00-16:25 Gender differences in metabolism
Adriana Maggi
Professor of Pharmacological Biotechnologies, University of Milan, adriana.maggi@unimi.it
16:25-16:50 “Gene-by-sex interactions regulating mitochondrial functions and cardio-metabolic traits”
Aldons Jake Lusis
16:50-17:15 “Sex differences in brain development and function: Implications for comorbidity of psychiatric and cardiovascular outcomes”
Jill Goldstein
Professor of Psychiatry and Medicine, Harvard Medical School; Executive Director, Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, jill_goldstein@hms.harvard.edu
17:15-17:30 Break
17:30-18:00 ICPI life time achievement cancer prevention award
Tony Howell
http://www.breastcentre.manchester.ac.uk/Research-Groups/Tony-Howell
Anthony.Howell@manchester.ac.uk
18:00-18:50 Poster awards (with awardees’ speed talks)
18:50-19:15 Sexual dimorphism in cancer : meeting overview
Sarah Seton.Rogers
Chief Editor, Nature Reviews Cancer
S.Seton-Rogers@nature.com
19:15 – 19:30 Concluding remarks
G. Paolo Dotto