Sexual dimorphism in cancer
April 1-4 2020, Epalinges (Lausanne)
PROGRAM (preliminary draft, Nov 11 2919)
Apr. 1
1. RATIONALE FOR CONSIDERING SEX-DETERMINING FACTORS IN CANCER PREVENTION AND TREATMENT
14.15 Gian Paolo Dotto – Welcoming remarks
14.30 – 15. Sabine Oertelt-Prigione – Ongoing efforts in gender medicine
Professor of Gender in Primary and Transmural Care, Radboud University , Nijmegen, The Netherlands (Sabine.Oertelt-Prigione@radboudumc.nl)
15- 15.30. Stuart Tobet – Sex, Gender, and sex steroids: What can brain sexual differentiation teach us about cancer biology?
Director, School of Biomedical Engineering, Professor, Department of Biomedical Sciences (Stuart.Tobet@ColoState.EDU)
15.30 – 16. Valery Lemmens – sex differences in epidemiology of non-sex related cancers
Scientific director of the Netherlands Cancer Registry (v.lemmens@iknl.nl )
16 – 16.30. coffee break
16.30 – 17. Jaakko Kaprio – Twins, hormones and cancer risk factors
Professor of Genetic Epidemiology, Department of Public Health, Faculty of Medicine & Institute for Molecular Medicine FIMM, HiLIFE University of Helsinki (jaakko.kaprio@helsinki.fi)
17-17.15. Short Talk
17.15-17.30 – Short Talk
18.00 – 20 Social mixer and light dinner
Apr. 2
2. X AND Y CHROMOSOMES
9-9.30 – David Page – Y chromosome evolution
Director, Whitehead Institute (dcpage@wi.mit.edu)
9.30-10 – Robin.Lovell-Badge – genetic basis of sex determination
head of the Laboratory of Stem Cell Biology and Developmental Genetics at the Francis Crick Institute
(Robin.Lovell-Badge@crick.ac.uk)
10-10.15 – short talk
10.15-10.30 – short talk
10-30-11 break
11-11.30 – Laura Zannini – “Gender specificity in DNA damage response pathways”
Group leader, Institute of Molecular Genetics, National Research Council (IGM-CNR), Pavia, IT laura.zannini@igm.cnr.it
11.30-11.45- short talk
11.45-12- short talk
12-12.30 – Jeannie Lee – X chromosome silencing and biological impact
Professor of Genetics (Pathology), Harvard Medical School, Molecular Biologist, Massachusetts General Hospital (lee@molbio.mgh.harvard.edu)
12.30 – 14.30 Lunch
Apr. 2
14 .30-18.30pm
3. SEX HORMONES
14.30- 15 – Eva Estébanez-Perpina – AR structure/function
Group leader Institute of Biomedicine of the University of Barcelona (IBUB) (evaestebanez@ub.edu)
15-15.30 -Matti Poutanen: Role of local sex steroid synthesis and metabolism in hormonal carcinogenesis
Professor of Physiology, Institute of Biomedicine, University of Turku, Finland matpou@utu.fi
15.30-16 – Miguel Beato del Rosal : nuclear architecture and gene regulation
Group leader, Center for Genomic Regulation (CGR) Barcelona <miguel.beato@crg.eu>
16-16.30 Coffee Break
16.30-16.45– short talk
16.45-17 – short talk
17-17.30 – Luca Magnani : Finding Dory: hormone exposure, mutational signatures and estrogen receptor defines the early oncogenesis processes at play in the cell of origin of breast cancer
Group leader, Imperial College London l.magnani@imperial.ac.uk
17.30-18 – Barbara Demeneix : endocrine disruption and the neural stem cell compartment
barbara.demeneix@mnhn.fr
6.00 -8 pm Poster session
8-10 pm Dinner
Apr 3
4. SPECIFIC ORGAN AND CANCER TYPES (GENETIC / MOLECULAR STUDIES)
9-9.30 – Paul C. Boutros – “The molecular epidemiology of somatic mutations: how does patient sex influence cancer evolution?”
Group leader, UCLA PBoutros@mednet.ucla.edu
9.30-10 – Cathrin Brisken – sex hormones in breast development and cancer
Group leader, Swiss Federal Institute of Technology Lausanne (EPFL) cathrin.brisken@epfl.ch
10-10.30 – Wilbert Zwart – sex hormones signaling in male breast cancer
Group leader, Netherlands Cancer Institute (NKI) w.zwart@nki.nl
10.30-11 coffee break
11-11.15 – short talk
11.15-11.30 – short talk
11.30 – 12 Todd Ridky – ER signaling and Melanoma
Group leader Department of Dermatology, U. Penn (ridky@pennmedicine.upenn.edu)
12 – 12.30 Soumitra Gosh / Min Ma AR signaling in skin cancer
UNIL, Department of Biochemistry
12.30 – 14.30 Lunch
14.30-15 – Alexandros Tzatsos – Pancreatic Cancer
Group leader, School of Medicine and Health Science, George Washington University (atzatsos@email.gwu.edu)
15- 15.30 – Margaret Anne Knowles – Bladder Cancer
Head of Section of Molecular Oncology, Leeds Institute of Cancer Studies and Pathology (M.A.Knowles@leeds.ac.uk)
15.30-15.45 – short talk
15.45-16 – short talk
16-16.30 coffee break
16.30-17 – Irene Miguel-Aliaga – The sex of the intestine and why it matters
Genes and Metabolism Section Chair, MRC London Institute of Medical Sciences, and Professor of Genetics and Physiology, Imperial College (i.miguel-aliaga@lms.mrc.ac.uk)
17-17.30 – Joshua B. Rubin – Sex differences in glioblastoma Professor of Pediatrics, Hematology and Oncology, Washington University School of Medicine in St. Louis (rubin_j@wustl.edu)
17.30-17.45 – short talk
17.45-18 – short talk
18-20 poster session
20 Dinner
Apr 4
6. IMMUNE SYSTEM, METABOLISM AND THE MICROBIOME
9-9.30 – Adriana Maggi – Gender differences in metabolism
Professor of Pharmacological Biotechnologies, University of Milan (adriana.maggi@unimi.it)
9.30-10 – Aldons Jake Lusis – “Gene-by-sex interactions regulating mitochondrial functions and cardio-metabolic traits”
10.00-10.30 break
7. FRONTIERS AND OPPORTUNITIES
10.30-11.00 – Anna Dorothea Wagner and Berna Ozdemir Toxicology, drug response and immune therapy CHUV
11.00-11.30 – Allan Balmain – genetic determinants of cancer susceptibility : a look to the future
Professor of Cancer Genetics, UCSF Allan.Balmain@ucsf.edu
11.30-12.00 – ICPI life time achievement cancer prevention award : Tony Howell
12.00-12.15 Concluding remarks : GP Dotto