This training network is based on the unifying guiding hypothesis that sex hormone action (Work Package 1) and chronic inflammation (Work Package 2) are important determinants of increased cancer risk in aging populations, and that insights in these fields can be used for novel translational applications (Work Package 3). As illustrated in the figure, we will focus on breast and skin cancer as benchmarks of major clinical significance, in organs with reproductive and non-reproductive functions, respectively. The enrolled PhD students (ESRs) will address the links between sex hormone signaling, persistent chronic inflammation, and genetic and behavioral/environmental cancer risk factors. They will devote most of their time and efforts to develop an in depth research project in one of the main participating laboratories under the direct supervion of one of the Principla Investigators (PIs). However, they are expected to further develop and carry out some of their research work in one or more of the other participating laboratories, under the joint supervision of other PIs. On top of rigorous research training, an essential objective of the program is for students to develop scientific communication and outreach skills, which may lead to new career opportunities in academia or the private sector.
Summary of CANCERPREV research topics and interactions. CANCERPREV studies breast and skin cancer as benchmarks of cancer development in organs with reproductive or non-reproductive functions (B). The unifying hypothesis is that deregulation of sex hormone signaling (WP1) and inflammation (WP2) play key roles in susceptibility and premalignant to malignant conversion of both tumor types, and that insights can be exploited clinically (WP3).
Participating laboratories and available research projects
This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 859860