Publications

CANCERPREV-related publications and highlights by participating laboratories 

Altun Mikael

• P, Boström J, Rullman E, Rudd SG, Vesterlund M,  Lehtiö J, Helleday T, Maddalo G,  Altun M. (2020), Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics., Molecular & cellular proteomics: MCP (608-623). PMID: 32051232
• Zhang SM,  Desroses M,  Hagenkort A,  Altun M. et al., (2020). Development of a chemical probe against NUDT15., Nature chemical biology 2020 (1120-1128). PMID: 32690945

Brisken Cathrin

• Cartaxo, AL., Estrada, M., Domenici, G., Roque, R., Silva, F., Gualda, EJ., Loza-Alvarez, P.,  Sflomos, G., and Brisken, C. , Alves, PM., André, S., Brito, C., (2020). A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures. J Exp Clin Cancer Res (S1535-6108(20)30311-1.). doi: 10.1186/s13046-020-01653-4
• Siersbæk, R., Scabia, V., Chernukhin, I., Papachristou, E.,  Broome, R., Green, A.,  Joosten, S., Kumar, S., Alvarez, R., Nagarajan, S., Glont, S., Omarjee S., Aitken, S., Kishore,K., Rakha, E., D’Santos, C., Zwart, W., Russell, A., Brisken, C, Carroll. (2020), IL6/STAT3 co-opts ER regulatory elements to drive metastasis in breast cancer. Cancer Cell. 2020 Jul 6:S1535-6108(20)30311-1. doi: 10.1016/j.ccell.2020.06.007.
• Ataca, D.^*, Aouad, P.^*, Constantin, C.^*, Laszlo, C. F., Beleut, M., Shamseddin M., Rajaram, R. D., Jeitziner, R., Mead, T.J., Caikovski, M., Bucher, P., Ambrosini G., Apte, S.S., Brisken, C. (2020). The secreted protease Adamts18 links mammary epithelial hormone action to extracellular matrix changes and stem cell niche function. Nat Commun. (11(1):1571). doi: 10.1038/s41467-020-15357-y.
• Gagniac, L., Rusidze, M., Boudou, F., Cagnet, S., Adlanmerini, Jeannot, P., M., Weyl, F., Boudou, A., Raymond-Letron, I., Besson, A., Arnal, JF, Brisken, C., Lenfant, F. (2020)., Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium. Development (147(5)),. doi: 10.1242/dev.182303 pii: dev182303
• Brisken C, Scabia V. (2020)., Progesterone receptor signalling in the normal breast and its implications for cancer. J Mol Endocrinol. pii: JME-20-0091.R1. doi: 10.1530/JME-20-0091

Chiorino Giovanna

• Patel A, Garcia LF, Mannella V, Gammon L, Borg TM, Maffucci T, Scatolini M, Chiorino G, Vergani E, Rodolfo M, Maurichi A, Posch C, Matin RN, Harwood CA, Bergamaschi D., (2020). Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma. Cancer Res (80(12):2676-2688). PMID: 32291316 doi: 10.1158/0008-5472.CAN-19-3230
• Peraldo-Neia C, Ostano P, Mello-Grand M, Guana F, Gregnanin I, Boschi D, Oliaro-Bosso S, Pippione AC, Carenzo A, De Cecco L, Cavalieri S, Micali A, Perrone F, Averono G, Bagnasacco P, Dosdegani R, Masini L, Krengli M, Aluffi-Valletti P, Valente G, Chiorino G. AKR1C3 is a biomarker and druggable target for oropharyngeal tumors. Cell Oncol (Dordr). 2020 Nov 19. doi: 10.1007/s13402-020-00571-z. Epub ahead of print. PMID: 33211282.
• Scatolini, M., Patel, A., Grosso, E., Mello-Grand, M., Ostano, P., Coppo, R., Vitiello, M., Venesio, T., Zaccagna, A., Pisacane, A., Sarotto, I., Taverna, D., Poliseno, L., Bergamaschi, D., & Chiorino, G. GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma. doi: https://doi.org/10.1111/bjd.20629

De Clerq Wim

• Aaes TL, Verschuere H, Kaczmarek A, Heyndrickx L, Wiernicki B, Delrue I, De Craene B, Taminau J, Delvaeye T, Bertrand MJM, Declercq W, Berx G, Krysko DV, Adjemian S, Vandenabeele P. Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection. J Immunol. 2020 Feb 15;204(4):775-787. doi: 10.4049/jimmunol.1900072. Epub 2020 Jan 3. PMID: 31900335.
• Devos M, Tanghe G, Gilbert B, Dierick E, Verheirstraeten M, Nemegeer J, de Reuver R, Lefebvre S, De Munck J, Rehwinkel J, Vandenabeele P, Declercq W, Maelfait J. Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation. J Exp Med. 2020 Jul 6;217(7):e20191913. doi: 10.1084/jem.20191913. PMID: 32315377; PMCID: PMC7336309.
• Hoste E, Maueröder C, van Hove L, Catrysse L, Vikkula HK, Sze M, Maes B, Karjosukarso D, Martens L, Gonçalves A, Parthoens E, Roelandt R, Declercq W, Fuentes I, Palisson F, Gonzalez S, Salas-Alanis JC, Boon L, Huebener P, Mulder KW, Ravichandran K, Saeys Y, Schwabe RF, van Loo G. Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation. Cell Rep. 2019 Nov 26;29(9):2689-2701.e4. doi: 10.1016/j.celrep.2019.10.104. PMID: 31775038.
• Konieczny P, Lichawska-Cieslar A, Kwiecinska P, Cichy J, Pietrzycka R, Szukala W, Declercq W, Devos M, Paziewska A, Rumienczyk I, Kulecka M, Mikula M, Fu M, Borowczyk J, Santamaria-Babí LF, Jura J. Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation. J Mol Med (Berl). 2019 Dec;97(12):1669-1684. doi: 10.1007/s00109-019-01853-2. Epub 2019 Nov 30. PMID: 31786670.
• Lichawska-Cieslar A, Konieczny P, Szukala W, Declercq W, Fu M, Jura J. Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118866. doi: 10.1016/j.bbamcr.2020.118866. Epub 2020 Sep 29. PMID: 33007332.
• Martens S, Hofmans S, Declercq W, Augustyns K, Vandenabeele P. Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs. Trends Pharmacol Sci. 2020 Mar;41(3):209-224. doi: 10.1016/j.tips.2020.01.002. Epub 2020 Feb 5. PMID: 32035657.

Dotto Gian Paolo

• Katarkar, A., Bottoni, G., Clocchiatti, A., Goruppi, S., Bordignon, P., Lazzaroni^, F., Gregnanin, I., Ostano, P., Neel,V., and G.P. Dotto (2020) NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin. Nature Comm. 2020. doi:10.1038/s41467-020-18919-2  For highlights click here

• Ma, M., Ghosh,S., Tavernari, D., Katarkar, A., Clocchiatti, A., Mazzeo,L., Samarkina, A., Epiney, Yu, Y._R. Ho, P.-C., Levesque, M.P. Özdemir, B.C., Ciriello, G., Dummer, R. and G.P. Dotto(2020) Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis. J. Exp. Med. 2020 e20201137. Doi : doi.org/10.1084/jem.20201137 For highlights click here

Kaprio Jaakko

• Mars N, Widén E, Kerminen S, Meretoja T, Pirinen M, Della Briotta Parolo P, Palta P; FinnGen, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S. The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nat Commun. 2020 Dec 14;11(1):6383. doi: 10.1038/s41467-020-19966-5. PMID: 33318493.
• Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB. Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Nat Commun. 2020 Nov 3;11(1):5562. doi: 10.1038/s41467-020-19265-z. PMID: 33144568; PMCID: PMC7642344.
• Brumpton B, Sanderson E, Heilbron K, Hartwig FP, Harrison S, Vie GÅ, Cho Y, Howe LD, Hughes A, Boomsma DI, Havdahl A, Hopper J, Neale M, Nivard MG, Pedersen NL, Reynolds CA, Tucker-Drob EM, Grotzinger A, Howe L, Morris T, Li S; Within-family Consortium; 23andMe Research Team, Auton A, Windmeijer F, Chen WM, Bjørngaard JH, Hveem K, Willer C, Evans DM, Kaprio J, Davey Smith G, Åsvold BO, Hemani G, Davies NM. Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nat Commun. 2020 Jul 14;11(1):3519. doi: 10.1038/s41467-020-17117-4. PMID: 32665587; PMCID: PMC7360778.
• García-González J, Brock AJ, Parker MO, Riley RJ, Joliffe D, Sudwarts A, Teh MT, Busch-Nentwich EM, Stemple DL, Martineau AR, Kaprio J, Palviainen T, Kuan V, Walton RT, Brennan CH. Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. Elife. 2020 Mar 25;9:e51295. doi: 10.7554/eLife.51295. PMID: 32209227; PMCID: PMC7096180.

Hess Kathryn

• Hess K. (2020) Topological Adventures in Neuroscience. In: Baas N., Carlsson G., Quick G., Szymik M., Thaule M. (eds) Topological Data Analysis. Abel Symposia, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-030-43408-3_11
• Fournier M, Scolamiero M, Gholam-Rezaee MM, Cleusix M, Jenni R, Ferrari C, Golay P, Baumann PS, Cuenod M, Conus P, Do KQ, Hess K. Topology predicts long-term functional outcome in early psychosis. Mol Psychiatry. 2020 Jul 6. doi: 10.1038/s41380-020-0826-1. Epub ahead of print. PMID: 32632207.

Kasper Maria

• Lichtenberger BM, Kasper M. Cellular heterogeneity and microenvironmental control of skin cancer. Journal of Internal Medicine. 2020 Sep. DOI: 10.1111/joim.13177.
• Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R, Kasper M. The Molecular Anatomy of Mouse Skin during Hair Growth and Rest. Cell Stem Cell. 2020 Mar 5;26(3):441-457.e7. doi: 10.1016/j.stem.2020.01.012. Epub 2020 Feb 27. PMID: 32109378.
• Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Füllgrabe A, Gerling M, Kasper M. Coordinated hedgehog signaling induces new hair follicles in adult skin. Elife. 2020 Mar 17;9:e46756. doi: 10.7554/eLife.46756. PMID: 32178760; PMCID: PMC7077985.
• Zhang Y, Annusver K, Sunadome K, Kameneva P, Edwards S, Lei G, Kasper M, Chagin AS, Adameyko I, Xie M. Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis. Front Cell Dev Biol. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122. PMID: 32211405; PMCID: PMC7066500.
• Norum JH, Frings O, Kasper M, Bergholtz H, Zell Thime H, Bergström Å, Andersson A, Kuiper R, Fredlund E, Sørlie T, Toftgård R. GLI1-induced mammary gland tumours are transplantable and maintain major molecular features. Int J Cancer. 2020 Feb 15;146(4):1125-1138. doi: 10.1002/ijc.32522. Epub 2019 Jul 8. PMID: 31219615.

Verschuren Emmy

• Talwelkar SS, Mäyränpää MI, Søraas L, Potdar S, Bao J, Hemmes A, Linnavirta L, Lømo J, Räsänen J, Knuuttila A, Wennerberg K, Verschuren EW. Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments. bioRxiv 2020.08.12.247817; doi: https://doi.org/10.1101/2020.08.12.247817
• Bao J, Närhi K., Teodòsio A, Hemmes A, Linnavirta NM, Mäyränpää MI, Salmenkivi K, Le Quesne J, Verschuren EW The role of SOX9 in non-small cell lung cancer progression is histopathology-selective. doi: https://doi.org/10.1101/2020.11.23.393926; https://www.biorxiv.org/content/10.1101/2020.11.23.393926v1
• Tervonen TA, Pant SM, Belitškin D, Englund JA, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. Oncogenic Ras disrupts epithelial integrity by activating transmembrane serine protease hepsin. In press, Cancer Res.
• Talwelkar,S., Mäyränpää, M., Søraas, L., Potdar, S., Bao, J,, Hemmes,A., Linnavirta, N., Lømo, J, Räsänen,J,, Knuuttila, A, Wennerberg,K. Verschuren, EW. Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments. doi: https://doi.org/10.1016/j.xcrm.2021.100373

Wagner Erwin

• Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M. Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells. doi: https://doi.org/10.15252/emmm.202012409
• Philipp Novoszel , Barbara Drobits  , Martin Holcmann   , Cristiano De Sa Fernandes   , Roland Tschismarov   , Sophia Derdak, Thomas Decker   , Erwin F Wagner  , Maria Sibilia. The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity. doi: https://doi.org/10.1038/s41418-021-00765-4 
• Matsuoka K, Bakiri L, Wolff LI, Linder M, Mikels-Vigdal A, Patiño-García A, Lecanda F, Hartmann C, Sibilia M, Wagner EF. Wnt signaling and Loxl2 promote aggressive osteosarcoma. Cell Res. 2020 Oct;30(10):885-901. doi: 10.1038/s41422-020-0370-1. Epub 2020 Jul 20. PMID: 32686768; PMCID: PMC7608146.